PUBLICATIONS

Bose M., Suresh V., Mishra U., Talwar I., Yadav A., Biswas S., Hippenmeyer S. and Tole S. 2024.  Dual role of FOXG1 in regulating gliogenesis in the developing neocortex via the FGF signaling pathway.  reviewed preprint, eLife

*Srivastava M, *Suresh V, and Tole S. Analysis of downstream targets of fundamental regulators of the developing mammalian neocortex, PAX6 and LHX2.  in press, J. Biosciences

Suresh, V., Bhattacharya, B., Tshuva, R.Y., Gotthold, M.D., Olender, T., Bose, M., Pradhan, S.J., Zeev, B.B., Smith, R.S., Tole, S. and Galande, S., 2024. PRDM16 co-operates with LHX2 to shape the human brain. Oxford Open Neuroscience, p.kvae001.

*Suresh, V., *Muralidharan, B., *Pradhan, S.J., Bose, M., D’Souza, L., Parichha, A., Reddy, P.C., #Galande, S. and #Tole, S., 2023. Regulation of chromatin accessibility and gene expression in the developing hippocampal primordium by LIM-HD transcription factor LHX2. PLoS Genetics, 19(8), p.e1010874.

Parichha, A., Datta, D., Suresh, V., Chatterjee, M., Holtzman, M.J. and Tole, S., 2022. Dentate gyrus morphogenesis is regulated by β-catenin function in hem-derived fimbrial glia. Development, 149(21), p.dev200953.

*Paricha, A., *Suresh, V., Chatterjee, M., Kshirsagar, A., Ben-Reuven, L., Olender, T., Taketo, M.M., Radosevic, V., Bobic-Rasonja, M., Trnski S., Holtzman, M. J., Jovanov-Milošević N., Reiner, O., Tole, S., 2022. Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelium fate. Nature Communications, 13, p.633.

Pal, S., Dwivedi, D., Pramanik, T., Godbole, G., Iwasato, T., Jabaudon, D., Bhalla, U.S. and Tole, S., 2021. An early cortical progenitor-specific mechanism regulates thalamocortical innervation. Journal of Neuroscience, 41(32), pp.6822-6835. 

Kinare, V., Iyer, A., Padmanabhan, H., Godbole, G., Khan, T., Khatri, Z., Maheshwari, U., Muralidharan, B. and Tole, S., 2020. An evolutionarily conserved Lhx2-Ldb1 interaction regulates the acquisition of hippocampal cell fate and regional identity. Development, 147(20). 

Tole, S. and Hebert, J., 2020. Telencephalon Patterning. Patterning and Cell Type Specification in the Developing CNS and PNS: Comprehensive Developmental Neuroscience, 1, p.3.  

Iyer, A. and Tole, S., 2019. Neuronal diversity and reciprocal connectivity between the vertebrate hippocampus and septum. Wiley Interdisciplinary Reviews: Developmental Biology, 9(4), p.e370. 

Kinare, V., Pal, S. and Tole, S., 2019. LDB1 is required for the early development of the dorsal telencephalon and the thalamus. Eneuro, 6(1). 

Chou, S.J. and Tole, S., 2019. Lhx2, an evolutionarily conserved, multifunctional regulator of forebrain development. Brain Research, 1705, pp.1-14. 

Chizhikov, V.V., Iskusnykh, I.Y., Steshina, E.Y., Fattakhov, N., Lindgren, A.G., Shetty, A.S., Roy, A., Tole, S. and Millen, K.J., 2019. Early dorsomedial tissue interactions regulate gyrification of distal neocortex. Nature Communications, 10(1), pp.1-13. 

Muralidharan, B., D’Souza, L. and Tole, S., 2018. An Efficient System for Gene Perturbation in Embryonic Hippocampal Progenitors Using Ex Vivo Electroporation Followed by In Vitro Dissociated Cell Culture. Journal of Experimental Neuroscience, 12, p.1179069518767404. 

Iyer, A., Subramanian, L. and Tole, S., 2018. Organotypic Explants of the Embryonic Rodent Hippocampus: An Accessible System for Transgenesis. Bio-protocol, 8(6). 

Godbole, G., Shetty, A.S., Roy, A., D'Souza, L., Chen, B., Miyoshi, G., Fishell, G. and Tole, S., 2018. Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon. Development, 145(1). 

Kinare, V., Shetty, A.S., Suresh, A. and Tole, S., 2018. PAX6 can substitute for LHX2 and override NFIA-induced astrogliogenesis in developing hippocampus in vivo. Journal of Biosciences, 43(1), pp.75-83. 

Godbole, G., Roy, A., Shetty, A.S. and Tole, S., 2017. Novel functions of LHX2 and PAX6 in the developing telencephalon revealed upon combined loss of both genes. Neural Development, 12(1), pp.1-8. 

Muralidharan, B., Keruzore, M., Pradhan, S.J., Roy, B., Shetty, A.S., Kinare, V., D'Souza, L., Maheshwari, U., Karmodiya, K., Suresh, A. and Galande, S., 2017. Dmrt5, a Novel Neurogenic Factor, Reciprocally Regulates Lhx2 to Control the Neuron–Glia Cell-Fate Switch in the Developing Hippocampus. Journal of Neuroscience, 37(46), pp.11245-11254. 

Muralidharan, B., Khatri, Z., Maheshwari, U., Gupta, R., Roy, B., Pradhan, S.J., Karmodiya, K., Padmanabhan, H., Shetty, A.S., Balaji, C., Kolthur-Seetharam, U., Macklis, J.D., Galande, S. and Tole, S., 2017. LHX2 interacts with the NuRD complex and regulates cortical neuron subtype determinants Fezf2 and Sox11. Journal of Neuroscience, 37(1), pp.194-203. 

Ruiz-Reig, N., Andrés, B., Huilgol, D., Grove, E.A., Tissir, F., Tole, S., Theil, T., Herrera, E. and Fairén, A., 2017. Lateral thalamic eminence: a novel origin for mGluR1/Lot cells. Cerebral Cortex, 27(5), pp.2841-2856. 

Huilgol, D. and Tole, S., 2016. Cell migration in the developing rodent olfactory system. Cellular and Molecular Life Sciences, 73(13), pp.2467-2490. 

Divya, T.S., Lalitha, S., Parvathy, S., Subashini, C., Sanalkumar, R., Dhanesh, S.B., Rasheed, V.A., Divya, M.S., Tole, S. and James, J., 2016. Regulation of Tlx3 by Pax6 is required for the restricted expression of Chrnα3 in Cerebellar Granule Neuron progenitors during development. Scientific Reports, 6(1), pp.1-16. 

Roy, A., Gonzalez-Gomez, M., Pierani, A., Meyer, G. and Tole, S., 2014. Lhx2 regulates the development of the forebrain hem system. Cerebral Cortex, 24(5), pp.1361-1372. 

Shetty, A.S., Godbole, G., Maheshwari, U., Padmanabhan, H., Chaudhary, R., Muralidharan, B., Hou, P.S., Monuki, E.S., Kuo, H.C., Rema, V. and Tole, S., 2013. Lhx2 regulates a cortex-specific mechanism for barrel formation. Proceedings of the National Academy of Sciences, 110(50), pp.E4913-E4921. 

Lakhina, V., Subramanian, L., Huilgol, D., Shetty, A.S., Vaidya, V.A. and Tole, S., 2013. Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus. F1000Research, 2, pp.205.

Roy, A., de Melo, J., Chaturvedi, D., Thein, T., Cabrera-Socorro, A., Houart, C., Meyer, G., Blackshaw, S. and Tole, S., 2013. LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis. Journal of Neuroscience, 33(16), pp.6877-6884. 

Huilgol, D., Udin, S., Shimogori, T., Saha, B., Roy, A., Aizawa, S., Hevner, R.F., Meyer, G., Ohshima, T., Pleasure, S.J. and Zhao, Y., 2013. Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream. Nature Neuroscience, 16(2), pp.157-165. 

Falnikar, A., Tole, S., Liu, M., Liu, J.S. and Baas, P.W., 2013. Polarity in migrating neurons is related to a mechanism analogous to cytokinesis. Current Biology, 23(13), pp.1215-1220. 

Chatterjee, M., Huilgol, D. and Tole, S., 2012. Building the Body, Building the Brain. Journal of the Indian Institute of Science, 92(4), pp.369-376. 

Tole, S., 2012. Creating the cortex and the hippocampal organizer. International Journal of Developmental Neuroscience, 8(30), p.614. 

Harel, I., Maezawa, Y., Avraham, R., Rinon, A., Ma, H.Y., Cross, J.W., Leviatan, N., Hegesh, J., Roy, A., Jacob-Hirsch, J. and Rechavi, G., 2012. Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. Proceedings of the National Academy of Sciences, 109(46), pp.18839-18844. 

Marcos-Mondéjar, P., Peregrín, S., Li, J.Y., Carlsson, L., Tole, S. and López-Bendito, G., 2012. The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors. Journal of Neuroscience, 32(13), pp.4372-4385. 

Subramanian, L., Sarkar, A., Shetty, A.S., Muralidharan, B., Padmanabhan, H., Piper, M., Monuki, E.S., Bach, I., Gronostajski, R.M., Richards, L.J. and Tole, S., 2011. Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus. Proceedings of the National Academy of Sciences, 108(27), pp.E265-E274. 

Desouza, L.A., Sathanoori, M., Kapoor, R., Rajadhyaksha, N., Gonzalez, L.E., Kottmann, A.H., Tole, S. and Vaidya, V.A., 2011. Thyroid hormone regulates the expression of the sonic hedgehog signaling pathway in the embryonic and adult Mammalian brain. Endocrinology, 152(5), pp.1989-2000. 

Falnikar, A., Tole, S. and Baas, P.W., 2011. Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migration. Molecular Biology of the Cell, 22(9), pp.1561-1574. 

Piper, M., Barry, G., Hawkins, J., Mason, S., Lindwall, C., Little, E., Sarkar, A., Smith, A.G., Moldrich, R.X., Boyle, G.M. and Tole, S., 2010. NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1. Journal of Neuroscience, 30(27), pp.9127-9139. 

Subramanian, L., Remedios, R., Shetty, A. and Tole, S., 2009. Signals From the Edges: The Cortical Hem and Antihem in Telencephalic Development. In Seminars in Cell & Developmental Biology (Vol. 20, No. 6, pp. 712-718).   

Subramanian, L. and Tole, S., 2009. Mechanisms underlying the specification, positional regulation, and function of the cortical hem. Cerebral Cortex, 19(suppl_1), pp.i90-i95.

Mangale, V.S., Hirokawa, K.E., Satyaki, P.R., Gokulchandran, N., Chikbire, S., Subramanian, L., Shetty, A.S., Martynoga, B., Paul, J., Mai, M.V. and Li, Y., 2008. Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate. Science, 319(5861), pp.304-309.  

Hari, P., Deshpande, M., Sharma, N., Rajadhyaksha, N., Ramkumar, N., Kimura, K.I., Rodrigues, V. and Tole, S., 2008. Chip is required for posteclosion behavior in Drosophila. Journal of Neuroscience, 28(37), pp.9145-9150. 

Barry, G., Piper, M., Lindwall, C., Moldrich, R., Mason, S., Little, E., Sarkar, A., Tole, S., Gronostajski, R.M. and Richards, L.J., 2008. Specific glial populations regulate hippocampal morphogenesis. Journal of Neuroscience, 28(47), pp.12328-12340. 

Remedios, R., Huilgol, D., Saha, B., Hari, P., Bhatnagar, L., Kowalczyk, T., Hevner, R.F., Suda, Y., Aizawa, S., Ohshima, T. and Stoykova, A., 2007. A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nature Neuroscience, 10(9), pp.1141-1150. 

Saha, B., Hari, P., Huilgol, D. and Tole, S., 2007. Dual role for LIM-homeodomain gene Lhx2 in the formation of the lateral olfactory tract. Journal of Neuroscience, 27(9), pp.2290-2297. 

Lakhina, V., Falnikar, A., Bhatnagar, L. and Tole, S., 2007. Early thalamocortical tract guidance and topographic sorting of thalamic projections requires LIM-homeodomain gene Lhx2. Developmental Biology, 306(2), pp.703-713. 

Tole, S., Gutin, G., Bhatnagar, L., Remedios, R. and Hébert, J.M., 2006. Development of midline cell types and commissural axon tracts requires Fgfr1 in the cerebrum. Developmental Biology, 289(1), pp.141-151. 

Tole, S., Remedios, R., Saha, B. and Stoykova, A., 2005. Selective requirement of Pax6, but not Emx2, in the specification and development of several nuclei of the amygdaloid complex. Journal of Neuroscience, 25(10), pp.2753-2760. 

Banerjee, S.B., Rajendran, R., Dias, B.G., Ladiwala, U., Tole, S. and Vaidya, V.A., 2005. Recruitment of the Sonic hedgehog signalling cascade in electroconvulsive seizure‐mediated regulation of adult rat hippocampal neurogenesis. European Journal of Neuroscience, 22(7), pp.1570-1580. 

Sathanoori, M., Dias, B.G., Nair, A.R., Banerjee, S.B., Tole, S. and Vaidya, V.A., 2004. Differential regulation of multiple brain-derived neurotrophic factor transcripts in the postnatal and adult rat hippocampus during development, and in response to kainate administration. Molecular Brain Research, 130(1-2), pp.170-177. 

Remedios, R., Subramanian, L. and Tole, S., 2004. LIM genes parcellate the embryonic amygdala and regulate its development. Journal of Neuroscience, 24(31), pp.6986-6990. 

Vyas, A., Saha, B., Lai, E. and Tole, S., 2003. Paleocortex is specified in mice in which dorsal telencephalic patterning is severely disrupted. Journal of Comparative Neurology, 466(4), pp.545-553. 

Oh, L.Y., Denninger, A., Colvin, J.S., Vyas, A., Tole, S., Ornitz, D.M. and Bansal, R., 2003. Fibroblast growth factor receptor 3 signaling regulates the onset of oligodendrocyte terminal differentiation. Journal of Neuroscience, 23(3), pp.883-894. 

Bansal, R., Lakhina, V., Remedios, R. and Tole, S., 2003. Expression of FGF receptors 1, 2, 3 in the embryonic and postnatal mouse brain compared with PDGFRα, Olig2 and Plp/dm20: implications for oligodendrocyte development. Developmental Neuroscience, 25(2-4), pp.83-95. 

Subramanian, L., Lakhina, V., Padmanabhan, H. and Tole, S., 2003. Role of LIM-HD Genes in the Specification of Cell Identity. In Proc. Indian Natn Sci Acad. B69 No (Vol. 5, pp. 803-824). 

Bulchand, S., Subramanian, L. and Tole, S., 2003. Dynamic spatiotemporal expression of LIM genes and cofactors in the embryonic and postnatal cerebral cortex. Developmental Dynamics: An Official Publication of the American Association of Anatomists, 226(3), pp.460-469. 

Bulchand, S., Grove, E.A., Porter, F.D. and Tole, S., 2001. LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem. Mechanisms of Development, 100(2), pp.165-175.